Synapse loss in dementias
نویسندگان
چکیده
منابع مشابه
Contribution of asymmetric synapse loss to lateralizing clinical deficits in frontotemporal dementias.
BACKGROUND Synapse loss has been found to be the major correlate of cognitive decline in Alzheimer disease (AD), and prefrontal synapse loss has been found in patients with frontotemporal dementia (FTD). OBJECTIVE To see if our hypothesis that within each FTD case, regional synapse loss would correlate with lateralizing neuropsychologic and neurobehavioral deficits would be correct. DESIGN ...
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Advances in different neuroimaging modalities such as structural and functional Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET), (including FDG-PET and recent amyloid/tau tracers) have changed the role of neuroimaging in the diagnosis of dementias. Instead of only excluding other secondary diagnoses, neuroimaging has become a potential biomarker that evaluates the pathop...
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Synapse loss correlates with cognitive decline in aging and most neurological pathologies. Sensory perception changes often represent subtle dysfunctions that precede the onset of a neurodegenerative disease. However, a cause-effect relationship between synapse loss and sensory perception deficits is difficult to prove and quantify due to functional and structural adaptation of neural systems. ...
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Synapse elimination at the developing neuromuscular junction (NMJ) sculpts motor circuits, and synapse loss at the aging NMJ drives motor impairments that are a major cause of loss of independence in the elderly. Here we provide evidence that at the NMJ, both developmental synapse elimination and aging-related synapse loss are promoted by specific immune proteins, members of the major histocomp...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2010
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.22392